Patients should be cautioned about the risk of bleeding associated with the concomitant use of sarafem and nsaids, aspirin, or other drugs that affect coagulation see drug interactions .
Since cross reactivity, including bronchospasm, between aspirin and other non-steroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, etodolac capsules should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma.
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Even aspirin and quinine are known to induce tinnitus in some people.
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Some drugs which should not be co-administered with singulair or require dosage adjustments are aspirin, nsaids, rifampin, phenobarbital, dexamethasone, butalbital and carbamazepine.
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Other recent meta-analyses have examined the effect of aspirin on cvd events in patients with diabetes.
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